Testing drug combinations to slow aging

Testing drug combinations to slow aging

Aging is a complex multifactorial process, meaning that multiple pathways need to be targeted to effectively prevent or slow aging [1]. A number of molecular pathways are well known for influencing aging, but only a few have been successfully targeted with individual drugs, and these drugs do not individually target all aging pathways. However, combinations of these drugs might have the potenti...

Stay dynamic to slow aging

n page 803, Gourlay et al. report the first evidence that the actin cytoskeleton can affect release of reactive oxygen species (ROS) by mitochondria, and thus life span in yeast. Certain mutant Saccharo-myces cerevisiae strains with alleles that reduce actin dynamics possess defective mitochondria. The team O Cells with increased actin dynamics live longer. went on to show that such strains dis...

Complex Dietary Interventions to Slow Rates of Aging Complex Dietary Interventions to Slow Rates of Aging

Leishmania donovani Develops Resistance to Drug Combinations

Drug combinations for the treatment of leishmaniasis represent a promising and challenging chemotherapeutic strategy that has recently been implemented in different endemic areas. However, the vast majority of studies undertaken to date have ignored the potential risk that Leishmania parasites could develop resistance to the different drugs used in such combinations. As a result, this study was...

Polypharmacy versus Drug Combinations

Drug combinations have been known to be used either for increasing effcctivity or for decreasing side-efFects. It is only when multiple drugs are prescribed without adequate scientific evidence in their favour then such practices need careful scrutiny. Multiple drug use in psychiatry has recently gained currency and so require thoughtful consideration. The term polypharmacy is generally used to...